keenly Posted April 27, 2023 Report Share Posted April 27, 2023 I have been using the antihistamines Nytol and Sominex(diphenhydramine and promethazine) for over 18 months, with 12 months of that being a daily use. I am now having POTS issues I never had before and horrible balance problems. I feel wobbly and slightly dizzy with small head movements. Has anyone with POTS had issues like this? Even when sitting I feel like I will topple over. I never had any of this before I started with the sleep aids. Quote Link to comment Share on other sites More sharing options...
Pistol Posted April 28, 2023 Report Share Posted April 28, 2023 @keenly I get this type of dizziness when I take two benadryls. I am OK if I take just one. I wonder if maybe there is too much of it in your system? Quote Link to comment Share on other sites More sharing options...
keenly Posted April 28, 2023 Author Report Share Posted April 28, 2023 1 hour ago, Pistol said: @keenly I get this type of dizziness when I take two benadryls. I am OK if I take just one. I wonder if maybe there is too much of it in your system? Too much of what? You mean too little? Quote Link to comment Share on other sites More sharing options...
Pistol Posted April 28, 2023 Report Share Posted April 28, 2023 I am sorry @keenly, I meant that maybe you are taking too much antihistamine? Quote Link to comment Share on other sites More sharing options...
Bergbrow Posted April 30, 2023 Report Share Posted April 30, 2023 @keenly Im also concerned about long term use of diphenhydramine because of the research stating cognitive decline with long term use. Because of this, I avoid this class of antihistamine for long use. I also have balance issues and I know balance takes a lot of brain energy to keep my body upright and all. Don’t know if a different class will work for you but if you are noticing something cognitively, maybe try a different class of histamine. You can get more details by searching internet but here’s a clip and a link from Cleveland Clinic. I’ve read similar data in other references as well. Do antihistamines cause dementia?Long term use of some antihistamines may increase your risk of dementia. Diphenhydramine (Benadryl®) blocks the effects of a neurotransmitter called acetylcholine. This neurotransmitter is vital for memory and learning. Diphenhydramine increased the risk of dementia by 54% in one 3,000 patient study followed for seven years. https://my.clevelandclinic.org/health/drugs/21223-antihistamines Quote Link to comment Share on other sites More sharing options...
MikeO Posted April 30, 2023 Report Share Posted April 30, 2023 1 hour ago, Bergbrow said: @keenly Im also concerned about long term use of diphenhydramine because of the research stating cognitive decline with long term use. Because of this, I avoid this class of antihistamine for long use. I also have balance issues and I know balance takes a lot of brain energy to keep my body upright and all. Don’t know if a different class will work for you but if you are noticing something cognitively, maybe try a different class of histamine. You can get more details by searching internet but here’s a clip and a link from Cleveland Clinic. I’ve read similar data in other references as well. Do antihistamines cause dementia?Long term use of some antihistamines may increase your risk of dementia. Diphenhydramine (Benadryl®) blocks the effects of a neurotransmitter called acetylcholine. This neurotransmitter is vital for memory and learning. Diphenhydramine increased the risk of dementia by 54% in one 3,000 patient study followed for seven years. https://my.clevelandclinic.org/health/drugs/21223-antihistamines Good post...Yes antihistamines will affect cognitive functions. the newer drugs like claritin or allegra are better. my nurses have said to take them with caution. Benadryl is good if needed but should be used short term. Quote Link to comment Share on other sites More sharing options...
keenly Posted May 1, 2023 Author Report Share Posted May 1, 2023 18 hours ago, Bergbrow said: @keenly Im also concerned about long term use of diphenhydramine because of the research stating cognitive decline with long term use. Because of this, I avoid this class of antihistamine for long use. I also have balance issues and I know balance takes a lot of brain energy to keep my body upright and all. Don’t know if a different class will work for you but if you are noticing something cognitively, maybe try a different class of histamine. You can get more details by searching internet but here’s a clip and a link from Cleveland Clinic. I’ve read similar data in other references as well. Do antihistamines cause dementia?Long term use of some antihistamines may increase your risk of dementia. Diphenhydramine (Benadryl®) blocks the effects of a neurotransmitter called acetylcholine. This neurotransmitter is vital for memory and learning. Diphenhydramine increased the risk of dementia by 54% in one 3,000 patient study followed for seven years. https://my.clevelandclinic.org/health/drugs/21223-antihistamines Exactly. I used every night for 14 months, then 1/4 tab every 2 days since. Unfortunately if I try to boost acetylcholine with any supplement I get severe, and I mean wide awake, severe insomnia. I never had balance issues and dizziness before using these antihistamines. Quote Link to comment Share on other sites More sharing options...
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