laurab Posted April 27, 2013 Report Share Posted April 27, 2013 Hi everyone.I'm new to the forum. I have dysautonomia (OI, GP, likely IST, can't thermoregulate) secondary to EDS and Complex Regional Pain Syndrome.I've been on midodrine for a long time for the OI... I'm largely reliant on a wheelchair anyway because of the CRPS and associate , but without the midodrine I'm almost bed-bound because I faint as soon as I'm upright. I actually fainted and fell while transferring from bed to chair a couple of years ago and fractured my spine in multiple places. Question is - some four hours or so after taking the midodrine, I 'crash'. I get very tired, very cold and shaky, my heart races more than normal. Does anyone else experience this? Laura Quote Link to comment Share on other sites More sharing options...
Racer Posted April 27, 2013 Report Share Posted April 27, 2013 Yes, midodrine only lasts 4-5 hours max, so I would imagine most people who take midodrine experience the crash after it wears off. It seems the average dosage is 2-3 times a day for this reason.I can do anything when the med is in my system, but when my third pill of the day wears off it is time for me to relax and stay sitting Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted April 28, 2013 Report Share Posted April 28, 2013 Crps was associated with small fiber neuropathy recently as has oi in some cases. rebound effects are common with midodrine. Best thing to do is take another dose it try a vasocobstrictor with a longer half life. Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted April 28, 2013 Report Share Posted April 28, 2013 Sorry - or try a vasocobstrictir with a longer half life. Quote Link to comment Share on other sites More sharing options...
SpinnyC Posted April 28, 2013 Report Share Posted April 28, 2013 Typically I can feel the dose wearing off after about 3- 3 1/2 hours. The last pill of the day was the worst- that one was like taking a nose-dive. After a while I got used to it and it wasn't so bad... but my system seems to adjust to Midodrine in general. I can only be on a certain dose for so long before it becomes less effective and needs to be increased for me to continue seeing the same benefits. Quote Link to comment Share on other sites More sharing options...
corina Posted April 28, 2013 Report Share Posted April 28, 2013 HI Laura, welcome to the forum! Quote Link to comment Share on other sites More sharing options...
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